Fecal Calprotectin as early predictor for screening and relapse in pediatric chronic diarrhea in India


Original Article

Author Details : Gujjarlapudi Deepika*, Namburu Veeraiah, Syed Hassan Naveed, D. Nageshwar Reddy

Volume : 7, Issue : 4, Year : 2021

Article Page : 178-184

https://doi.org/10.18231/j.ijmpo.2021.036



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Abstract

Introduction: IBS and IBD are two abdomen ailments commonly seen in children. IBD is a life-long disorder that includes two major forms of chronic illness UC and CD, IBS may occur when the bowel is sensitive to specific foods or other triggers like stress.
Aims & Objective: The aims of the study is to investigate clinical usefulness of FC as early predictor for screening and differentiating IBD and IBS and to monitor the treatment for relapse and remission in pediatric Indian population.
Materials and Methods: This was hospital based observational cohort study, conducted over a period of twelve months from January 2019 to December 2019 Total 325 patients attending OPD were included in the study, in children between 1-18years in which FC was measured using commercially available CLIA kit. HB, ESR, Hscrp were also assessed, these patients were followed up.
Results: Patients were grouped asGroup I: IBS: 115(50:65M/F), Group II: 185 IBD, had Subgroup I:116 CD(48:68M/F);Group A: 62.7% presented with relapse Group B: 37.3% had disease in remission Subgroup II: 69 patients had UC(31:38 M/F); Group A: 60.9% had relapse and Group B: 39.1% in remission after follow up. Subgroup III: Others were 25(7.7%). In Study I: Levels of FC were significantly lower in patients with group I when compared to group II. In Subgroup I & Subgroup II Group A had higher FC levels when compared to group B. In Study II: A significant difference (P<0> Conclusion: The present study showed that the determination of FC assists to differentiate between IBD and IBS also useful in monitoring of remission and in early prediction of relapse in pediatric IBD.
 

Keywords: Inflammatory bowel diseases (IBD) and Irritable bowel syndrome (IBS), Crohn’s disease (CD), Ulcerative colitis (UC), Disease monitoring.


How to cite : Deepika G, Veeraiah N, Naveed S H, Reddy D N, Fecal Calprotectin as early predictor for screening and relapse in pediatric chronic diarrhea in India. IP Int J Med Paediatr Oncol 2021;7(4):178-184


Copyright © 2021 by author(s) and IP Int J Med Paediatr Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)





Article History

Received : 28-10-2021

Accepted : 20-11-2021

Available online : 22-12-2021


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https://doi.org/10.18231/j.ijmpo.2021.036


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