Author Details :
Volume : 3, Issue : 1, Year : 2017
Article Page : 42-44
A term 7 day old girl with phenotype of Down syndrome presented with irritability, poor feeding and respiratory distress for one day. She had echymotic patches on trunk and arm, moderate hepato-splenomegaly, swollen cyanosed cold right forearm. Neonatal sepsis was suspected but sepsis screen was negative. Peripheral blood smear revealed marked leucocytosis with 70% myeloblast cells, thrombocytopenia and normal erythrocyte count. Bone marrow had 48% myeloblasts. Differential diagnosis of transient abnormal myelopoiesis (with life threatening symptoms) and congenital leukemia were kept. We chose to report this case as it highlights the association between commonest chromosomal anomaly- Down syndrome and various hematological anomalies.
Keywords: Down Syndrome, Congenital Leukemia, Transient abnormal myelopoiesis
How to cite : Akter N, Agarwal V, Kumar P, Acute myeloid leukemia/ transient abnormal myelopoeisis masquerading as sepsis in a neonate with down syndrome. IP Int J Med Paediatr Oncol 2017;3(1):42-44
Copyright © 2017 by author(s) and IP Int J Med Paediatr Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)